Microbiome changes due to antibiotic prophylaxis in mothers at birth

We are conducting an exploratory, unblinded, monocentric, two-arm, non-interventional, observational study of dysbiosis due to prophylactic administration of cefuroxime.

The MAMA study is registered with the German Clinical Trials Register (Deutsches Register klinischer Studien, DRKS) under: DRKS00027305.

Cooperation partner

Patients are recruited at two level 1 perinatal centers: Women’s Clinic Holweide, Cologne Merheim Medical Centre and St. Marien Hospital, GFO Clinics Bonn. The study is conducted in cooperation with the German Aerospace Center (Deutsches Zentrum für Luft- und Raumfahrt, DLR, Prof. Dr. Ralf Möller), University of Applied Sciences Bonn-Rhein-Sieg (Hochschule Bonn-Rhein-Sieg, HBRS, Prof. Dr. Martin Sieber) and the Institute for Medical Microbiology, Immunology and Parasitology (IMMIP, Dr. Claudio Neidhöfer) of the University Hospital Bonn (UKB) in the context of a doctoral thesis (PhD student: Elisabeth Feles, pharmacist) at Witten/Herdecke University under the supervision of Prof. Dr. Frauke Mattner (Division of Hygiene and Environmental Medicine, Department of Human Medicine, Faculty of Health).


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Elisabeth Feles
Study Coordinator
PhD candidate

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Elisabeth Feles
Study Coordinator MAMA-Study

Kliniken der Stadt Köln
Institut für Hygiene, Haus 34
Ostmerheimer Straße 200
51109 Köln

Tel.: +49 221 8907-13438


The MAMA study is financed by research funds of Institute of Hygiene, Cologne Merheim Medical Centre, University Hospital of Witten/Herdecke.